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Adi Nugroho
Telkom University
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Journal : Jurnal Anestesi Perioperatif

 1 
Hubungan antara Rasio Neutrofil-Limfosit dan Skor Sequencial Organ Failure Assesment pada Pasien yang Dirawat di Ruang Intensive Care Unit Nugroho, Adi; -, Suwarman; Nawawi, A. Muthalib
Jurnal Anestesi Perioperatif Vol 1, No 3 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Respons fisiologis sistem imunitas terhadap inflamasi sistemik adalah peningkatan jumlah neutrofil dan penurunan jumlah limfosit atau peningkatan rasio neurofil-limfosit (RNL). Penelitian ini bertujuan untuk melihat hubungan inflamasi sistemik yang ditandai peningkatan RNL terhadap kegagalan fungsi organ ditandai dengan skor Sequencial Organ Failure Assessment (SOFA) pada pasien yang dirawat di Intensive Care Unit (ICU). Penelitian ini adalah penelitian observasional dengan rancangan penelitian cross sectional. Penelitian dilakukan dengan mengobsevasi RNL dan skor SOFA pada jam ke-0, jam ke-24, dan jam ke-48 dari 78 pasien yang dirawat di ICU Rumah Sakit Dr. Hasan Sadikin Bandung periode Desember 2012–Februari 2013 yang terbagi ke dalam 3 kategori sepsis A, B, dan C. Data penelitian dianalisis menggunakan analisis bivariabel dengan Uji Korelasi Pearson dan Spearman. Hasil penelitian menunjukkan hubungan antara RNL dan skor SOFA terhadap kategori sepsis masing-masing (p<0,001). Uji Korelasi Pearson didapatkan hubungan antara RNL dan skor SOFA (p<0,05; R=0,63). Simpulan, terdapat hubungan antara keadaan inflamasi sistemik yang ditandai dengan RNL dan kegagalan fungsi organ yang ditandai dengan skor SOFA pada pasien yang dirawat di ICU RS Dr. Hasan Sadikin Bandung.Kata kunci: Intensive care unit, rasio netrofit-limfosit, sequencial organ failure assesment Relationship between Neutrophil Lymphocyte Ratio and Sequential Organ Failure Assesment Score in the Intensive Care Unit patientsAbstractPhysiological response of immune system against systemic inflammation involves an increased level of neutrophils and a reduction of lymphocyte or an increase of neutrophil-lymphocyte ratio (RNL). The aim of this study was to identify the relationship between systemic inflammation, characterized by increasing in RNL on organ malfunction, assessed by Sequential Organ Failure Assessment (SOFA) score in Intensive Care Unit (ICU) patients. This study was a observational study with cross sectional design. This study was conducted by observing RNL and SOFA score at 0, 24th and 48th hour of 78 patients treated in the ICU Dr. Hasan Sadikin Hospital Bandung in December 2012–February 2013. Patients were divided into 3 categories of sepsis A, B and C. This study showed that there was a relationship between RNL, SOFA scores and sepsis categories (p<0.001). Pearson Correlation Test showed that there was relationship between RNL and SOFA scores (p<0.05, R= 0.63). In conclusion, there is a relationship between systemic inflammatory condition, characterized by RNL and organ failure, characterized by the SOFA score, in patients treated in the ICU Dr. Hasan Sadikin Hospital Bandung.Key words: Intensive care unit, neutrophil-lymphocyte ratio, sequential organ failure assesment DOI: 10.15851/jap.v1n3.198
Co-Authors A. Muthalib Nawawi Abdul Muchid, Abdul Agus Naryoso S.Sos, M.Si, Agus Naryoso Agus Setyawan Ahmad Ashari Amal Gamasi T.R Anggariawan, Arista Anjik Sukmaaji Arina, Arina Astuti Dwi Wahyu Pertiwi Bahrul Ilmi Baskoro Rochaddi Beta Himawan Putra, Beta Himawan Budiantoro, Cahyo Budiyantoro, Cahyo David Fredy Christiyanto, David Fredy Diah Rukmi Ambarwati, Diah Rukmi Dimas Herdy Utomo Djoko Setyabudi DR Sunarto Dwi Haryo Ismunarti Edi Winarko Fariza Khumaedi Handono Priambodo, Handono Hani Faurizka Hedi Pudjo Santosa Hettyca Astuningdyas Hutama, Adhi Setya Hutama, Adhi Setya Ikhsan, Subkhan Nur Irawati Sri Wulandari Joyo NS Gono Khabib Mustofa Lia Andriyani M Yulianto Marliani Marliani NANIK WAHYUNI Nurrist Suraya Ulfa Nurriyatul Lailiyah, Nurriyatul Oithona Gracelia R. Hutabarat, Oithona Gracelia R. Seno Darmanto Sosiati, Harini Sri Budi Lestari Suci Widyawati Sunarso Sugeng Sunarto Sunarto Suparto Suparto Suwarman - Teguh Sutanto Totok Suwanda Triyono Lukmantoro Turnomo Rahardjo Wibowonoto, Arif Widihastuti, Asti Yos Richard Beeh Yudha Setya Nugraha Yusriana, Amida